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BACKGROUND:Lung adenocarcinoma is histologically heterogeneous and has 5 distinct histologic growth patterns: lepidic, acinar, papillary, micropapillary, and solid. To date, there is no consensus regarding the clinical utility of these patterns.
METHODS:The authors performed a detailed semiquantitative assessment of histologic patterns of 240 lung adenocarcinomas and determined the association with...
BACKGROUND:In Nordic countries, the standard treatment of colorectal cancer (CRC) in the adjuvant setting is bolus 5‐fluorouracil (5‐FU) plus leucovorin alone or in combination with oxaliplatin. 5‐FU competes with the natural occurring pyrimidine uracil (Ura) as a substrate for dihydropyrimidine dehydrogenase (DPD; enzyme commission number 1.3.1.2). Low DPD activity is associated with toxicity during...
BACKGROUND:The goal of this study was to examine the clinical significance of ZNF217 amplification and assess whether ZNF217 could be a potential therapeutic target in ovarian clear cell carcinoma (OCCC).
METHODS:ZNF217 expression and amplification in OCCC was assessed by immunohistochemistry, fluorescence in situ hybridization, and clinical data collected via a retrospective chart review. ZNF217...
BACKGROUND:To identify potential genetic markers for severe oxaliplatin‐induced chronic peripheral neuropathy (OXCPN), the authors performed a genome‐wide association analysis of patients with colon cancer who received oxaliplatin‐based chemotherapy.
METHODS:This was a prospective study in which DNA was purified in peripheral blood from patients with colon cancer who received oxaliplatin. The primary...
BACKGROUND:A subset of patients with metastatic cancer in limited organs may benefit from metastasis‐directed therapy. The authors investigated whether patients with limited metastases could be safely treated with metastasis‐directed radiotherapy.
METHODS:Patients with 1 to 5 metastatic cancer sites with a life expectancy of >3 months received escalating stereotactic body radiotherapy (SBRT) doses...
BACKGROUND:Cancer survivors are particularly prone to the effects of a fragmented health care delivery system. The implications of fragmented cancer care across providers likely include greater spending and worse quality of care. For this reason, the authors measured relations between increasing fragmentation of cancer care, expenditures, and quality of care among prostate cancer survivors.
METHODS:A...
BACKGROUND:The objective of this study was to assess the efficacy of 90Y‐DOTA‐D‐Phe1‐Tyr3 octreotide (90Y‐DOTATOC) therapy with a fixed activity of 2.56 GigaBequerels bimonthly in patients with advanced stage, well differentiated neuroendocrine carcinomas.
METHODS:In total, 38 patients were enrolled in this phase 2A protocol. All patients had gastroenteropancreatic neuroendocrine tumors in sharp...
BACKGROUND:Recently, a highly sensitive fluorescent imaging technique was developed for the real‐time identification of hepatic tumors. The authors applied this procedure for the intraoperative detection of radiographically occult hepatic micrometastases from pancreatic cancer.
METHODS:Forty‐nine consecutive patients with pancreatic cancer who underwent surgical intervention were examined. Preoperative...
BACKGROUND:Malignant mesothelioma (MM) is an aggressive cancer of serosal membranes, mostly pleura. It is related to asbestos exposure and its incidence in most industrialized countries is projected to remain stable or to increase until 2020. Prognosis remains poor. Clinical prognostic scoring systems lack precision. No prognostic tissue markers are available. Aquaporin 1 (AQP1) is a cell membrane...
BACKGROUND:Breast cancer (BC) patients wonder how their daughters might reduce their risk. The authors investigated childhood/adolescent risk factors for benign breast disease (BBD), a well‐documented risk factor for BC, among girls with a family history.
METHODS:GUTS (the Growing Up Today Study) includes females, aged 9 to 15 years in 1996, who completed annual questionnaires during 1996 to 2001,...
BACKGROUND:This study assessed BRCA1 and BRCA2 mutation prevalence in an unselected cohort of patients with triple‐negative breast cancer (BC).
METHODS:One hundred ninety‐nine patients were enrolled. Triple negativity was defined as <1% estrogen and progesterone staining by immunohistochemistry and HER‐2/neu not overexpressed by fluorescence in situ hybridization. Having given consent, patients...
BACKGROUND:Neurosurgical resection is considered the standard treatment for most patients with a single brain metastasis. However, radiosurgery (RS) is a reasonable alternative. It was demonstrated that whole‐brain radiotherapy (WBRT) in addition to RS improves local control of 1‐3 brain metastases. Little information is available regarding WBRT in addition to RS for a single lesion.
METHODS:Data...
BACKGROUND:Doxorubicin (Adriamycin) is effective in gastric cancer treatment, but with severe dose‐dependent toxicities. A novel prodrug of doxorubicin (Ac‐Phe‐Lys‐PABC‐ADM) is designed to deliver free doxorubicin relying on cathepsin B and reduce side effects. The authors examined the antitumor effect and toxicities of Ac‐Phe‐Lys‐PABC‐ADM against gastric cancer peritoneal carcinomatosis.
METHODS:SGC‐7901...
BACKGROUND:Adenoid cystic carcinoma (ACC) is characterized by slow growth, frequent local recurrences, and distant metastasis (DM). However, these findings frequently are reported in patients with advanced‐stage tumors, but the outcomes of early‐stage tumors are poorly defined. We sought to evaluate the risk factors for the development of DM in early‐stage ACC.
METHODS:We retrospectively reviewed...
BACKGROUND:Isolated isochromosome (17q) is a rare cytogenetic abnormality in Philadelphia chromosome‐negative myeloid neoplasms, usually myelodysplastic and/or myeloproliferative neoplasms (MDS/MPN). De novo acute myeloid leukemia (AML) with isochromosome 17q has rarely been reported. The frequency of genetic mutations is unknown.
METHODS:The authors assessed clinicopathologic, immunophenotypic,...
BACKGROUND:The objective of this study was to evaluate the clinical benefits of systemic chemotherapy for patients with metastatic pheochromocytomas or sympathetic paragangliomas by assessing reductions in tumor size and blood pressure and improvements in overall survival (OS).
METHODS:The authors retrospectively reviewed the medical records of patients with metastatic pheochromocytomas‐sympathetic...
BACKGROUND:The authors previously observed that enhancer of zeste homolog 2 (EZH2) overexpression was associated significantly with the development of oral cancer. In the current study, they investigated whether EZH2 can function as a prognostic predictor for patients with head and neck squamous cell carcinoma (HNSCC).
METHODS:Expression levels of EZH2 in HNSCC cells were detected using reverse transcriptase‐polymerase...
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